The role of extracellular matrix in the exercise training-specific remodeling of white adipose tissues

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White adipose tissues(WAT) are remodeled due to exercise training(TR). The extracellular matrix(ECM), which encloses adipocytes, is thought to play an important role in remodeling of WAT. In the present study, therefore, the role of ECM in TR and obesity-specific remodeling of WAT was investigated. Expression of the gene for the dermatopontin(Dpt), which is one of the ECM, in WAT is higher in obese mice than in lean mice. TR definitely attenuated such obesity-induced Dpt gene expression in WAT. Moreover, TR enhanced expression of the ECM receptor integrinα1 gene in WAT. These results suggest that Dpt and integrinα1 are considered to be implicated in remodeling of WAT by TR.