The investigation of both FDG uptake mechanism and predicton prognosis using PET/CT in pancreatic cancer patients

我们研究了GLUT-1表达与胰腺癌进展相关的信号转导通路的相关性，以及18f -氟脱氧葡萄糖（FDG）摄取与这些信号转导通路的相关性。我们发现葡萄糖转运蛋白-1 （GLUT-1）的表达与表皮生长因子（EGFR）、P70、哺乳动物雷帕霉素靶蛋白（mTOR）、p -核蛋白和核蛋白在细胞系上的表达有关。对44例切除的胰腺癌标本进行了这些信号传递因子的免疫组化染色。采用最大标准化摄取值（SUV max）评价胰腺癌中FDG的摄取。原发性胰腺癌的SUV max与GLUT-1、GLUT-3、P70、EGFR表达显著相关。我们的数据提示胰腺癌FDG摄取机制与GLUT-1、mTOR相关信号转导通路和EGFR有关。

We investigated the correlation between GLUT-1 expression and signal transduction pathway related with pancreas cancer progression, and correlation between 18F-flurodeoxygluocose (FDG) uptake and these signal transduction pathway. We found that glucose transportwer-1 (GLUT-1) expression is associated with epidermal growth factor (EGFR), P70, mammalian target of rapamycin (mTOR), P-riboprotein, and riboproten on cell line. Immunohistochemical staining for these signal transfer factors was performed to 44 resected specimen of pancreas cancer. Maximum standardized uptake value (SUV max) was performed to evaluate the FDG uptake in pancreas cancer. SUV max of primary pancreas cancer correlated with GLUT-1, GLUT-3, P70 and EGFR expressions significantly. Our data suggest that FDG uptake mechanism of pancreas cancer is associated with GLUT-1, mTOR related signal transduction pathway and EGFR.