Molecular pathological evaluation of therapeutic effect using PET/CT in patients with esophageal cancer

探讨食管鳞状细胞癌（ESCC）患者中葡萄糖转运蛋白（GLUT-1）和血管内皮生长因子（VEGF）表达与氟-18-氟脱氧葡萄糖（^<18>F-FDG）摄取的关系。方法：对57例患者进行研究。男性52例，女性5例。^术前进行F-FDG正电子发射断层扫描/计算机断层扫描(PET)/CT。采用术后组织病理标本进行免疫组化（IHC）。采用评分法对IHC进行估计。我们研究了最大标准化摄取值（SUV max）与GLUT-1/VEGF表达/病理性肿瘤长度（p-tumor length）的相关性，病理T （p-T）分期与GLUT-1/VEGF表达/SUV max的关系，淋巴结转移（p-N）分期与GLUT-1/VEGF表达/SUV max的关系。结果：SUV max与GLUT-1表达及p-肿瘤长度呈显著相关[GLUT-1: r=0.475, p <0.001， p-肿瘤长度r=0.475, p <0.001]。原发肿瘤的SUV max与p- t分期、p- n分期、VEGF表达有显著关系[p- t分期：p <0.001， p- n分期：p=0.037， VEGF表达：p=0.009]。GLUT-1表达与p- t期/VEGF表达差异有统计学意义，p- n期差异无统计学意义（p- t期p=0.012， VEGF表达p=0.01， p- n期p=0.572）。VEGF表达与p- t分期有显著相关性，与p- n分期无显著相关性（p- t分期p=0.032， p- n分期p=0.763）。结论：我们的数据表明，18F-FDG的摄取可以通过glut -1和VEGF来确定。SUV max可能与肿瘤进展和淋巴结转移有关。

To examine the relationship between glucose transporter (GLUT-1) and vasoendothelial growth factor (VEGF) expression and fluorine-18-fluorodeoxyglucose (^<18>F-FDG) uptake in esophageal squamous cell cancer (ESCC) patients. Methods : Fifty-seven patients were included in this study. The patients consisted of 52 males and 5 females. ^<18>F-FDG positron emission tomography/computed tomography (PET)/CT was performed prior to the surgery. Immunohistochemistry (IHC) was performed using postoperative histopathological specimens. The estimation of IHC was conducted using scoring analysis. We investigated the correlations between maximum standardized uptake value (SUV max) and GLUT-1/VEGF expressions/pathological tumor length (p-tumor length), and the relationships between pathological T (p-T) stage and GLUT-1/VEGF expressions/SUV max and between lymph node metastasis (p-N) stage and GLUT-1/VEGF expressions/SUV max. Results : SUV max were significantly correlated with GLUT-1 expressions and p-tumor length [GLUT-1 : r=0.475, p < 0.001, p-tumor length : r=0.475, p <0.001]. SUV max of the primary tumor had a significant relationship with p-T stage, p-N stage, and VEGF expression [p-T stage : p <0.001, p-N stage : p=0.037, VEGF expression : p=0.009]. There was a statistically significant difference between GLUT-1 expression and p-T stage/VEGF expression but not p-N stage (p-T stage : p=0.012, VEGF expression : p=0.01, p-N stage : p=0.572). VEGF expression had a significant relationship with p-T stage but not p-N stage (p-T stage : p=0.032, p-N stage : p=0.763). Conclusion : Our data indicate that 18F-FDG uptake can be determined by GLUT-1and VEGF. SUV max would have a connection with the tumor progression and lymph node metastasis.