Molecular pathological evaluation of therapeutic effect using PET/CT in patients with esophageal cancer

食管癌PET/CT治疗效果的分子病理学评价

• 批准号: 20591465
• 负责人: ISHIBASHI Masatoshi
• 金额: $ 2.08万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591465/
• 关键词: 食道癌; PET; CT; FDG; GLUT family; VEGF; GLUT 1; GLUT 3; PET/CT; GLUT Family; GLUT1; GLUT3; GLUT 4; Akt

To examine the relationship between glucose transporter (GLUT-1) and vasoendothelial growth factor (VEGF) expression and fluorine-18-fluorodeoxyglucose (^<18>F-FDG) uptake in esophageal squamous cell cancer (ESCC) patients. Methods : Fifty-seven patients were included in this study. The patients consisted of 52 males and 5 females. ^<18>F-FDG positron emission tomography/computed tomography (PET)/CT was performed prior to the surgery. Immunohistochemistry (IHC) was performed using postoperative histopathological specimens. The estimation of IHC was conducted using scoring analysis. We investigated the correlations between maximum standardized uptake value (SUV max) and GLUT-1/VEGF expressions/pathological tumor length (p-tumor length), and the relationships between pathological T (p-T) stage and GLUT-1/VEGF expressions/SUV max and between lymph node metastasis (p-N) stage and GLUT-1/VEGF expressions/SUV max. Results : SUV max were significantly correlated with GLUT-1 expressions and p-tumor length [GLUT-1 : r=0.475, p < 0.001, p-tumor length : r=0.475, p <0.001]. SUV max of the primary tumor had a significant relationship with p-T stage, p-N stage, and VEGF expression [p-T stage : p <0.001, p-N stage : p=0.037, VEGF expression : p=0.009]. There was a statistically significant difference between GLUT-1 expression and p-T stage/VEGF expression but not p-N stage (p-T stage : p=0.012, VEGF expression : p=0.01, p-N stage : p=0.572). VEGF expression had a significant relationship with p-T stage but not p-N stage (p-T stage : p=0.032, p-N stage : p=0.763). Conclusion : Our data indicate that 18F-FDG uptake can be determined by GLUT-1and VEGF. SUV max would have a connection with the tumor progression and lymph node metastasis.

探讨食管鳞癌(ESCC)患者葡萄糖转运体(GLUT-1)、血管内皮生长因子(VEGF)表达与氟-18-脱氧葡萄糖(F-FDG)摄取的关系。方法：57例患者纳入本研究。患者包括52名男性和5名女性。术前行正电子发射断层扫描/计算机断层扫描(PET)/CT检查。免疫组织化学(IHC)检测术后组织病理标本。采用计分分析方法对IHC进行估算。研究最大标准摄取值(SUV Max)与GLUT-1/VEGF表达/病理肿瘤长度(p-肿瘤长度)的关系，病理T(p-T)分期与GLUT-1/VEGF表达/SUV max及淋巴结转移(p-N)分期与GLUT-1/VEGF表达/SUV max的关系。结果：SUVmax与GLUT-1表达和p-肿瘤长度显著相关[GLUT-1：r=0.475，p&lt；0.001，p-肿瘤长度：r=0.475，p&lt；0.001]。原发肿瘤的SUVmax与p-T分期、p-N分期及血管内皮生长因子表达显著相关[p-T分期：P&lt；0.001，p-N分期：P=0.037，血管内皮生长因子表达：P=0.009]。GLUT-1表达与p-T分期/血管内皮生长因子表达相比差异有统计学意义(p-T分期：P=0.012，P=0.01p-N分期：P=0.572)。血管内皮生长因子的表达与p-T分期有关，而与p-N分期无关(p-T分期：P=0.032，p-N分期：P=0.763)。结论：GLUT-1和血管内皮生长因子可作为判断18F-FDG摄取的指标。SUV_(Max)可能与肿瘤进展和淋巴结转移有关。

项目成果

他1分子病理学的手法を用いての食道癌へのFDG集積の特性解析

使用其他分子病理学方法表征食管癌中 FDG 的积累

• 发表时间: 2009
• 作者: 小林真衣子;甲斐田勇人;石橋正敏
• 通讯作者: 石橋正敏

The relationship between biologic factor and ^<18>F-FDG uptake in esophageal squamous cell cancer patients.

食管鳞状细胞癌患者生物因素与^ 18 F-FDG摄取之间的关系。

• 发表时间: 2010
• 作者: Kobayashi M;Ishibashi M;et al
• 通讯作者: et al

分子病理学的手法を用いての食道癌へのFDG集積の特性解析

使用分子病理学方法表征食管癌中 FDG 的积累

• 发表时间: 2009
• 作者: Zareen Fatima;Utaroh Motosugi;Masaaki Hori;Keiichi Ishigame;Hiroshi Kumagai;Satoshi Ikenaga;Toshiyuki Onodera;Tsutomu Araki;小林真衣子,甲斐田勇人,石橋正敏,他
• 通讯作者: 小林真衣子,甲斐田勇人,石橋正敏,他

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The relationship between biologic factor and 18F-FDG uptake in esophageal squamous cell cancer patients.

食管鳞癌患者生物因素与~(18)F-FDG摄取的关系。

• 发表时间: 2010
• 作者: 小林真衣子;石橋正敏;et al.
• 通讯作者: et al.