Molecular pathological evaluation of therapeutic effect using PET/CT in patients with esophageal cancer

目的探讨食管鳞状细胞癌（ESCC）患者葡萄糖转运蛋白（GLUT-1）、血管内皮生长因子（VEGF）表达与氟-18-脱氧葡萄糖（<18>FDG）摄取的关系。方法：57例患者纳入本研究。男52例，女5例。手术<18>前进行了13 F-FDG正电子发射断层扫描/计算机断层扫描（PET）/CT。使用术后组织病理学标本进行免疫组织化学（IHC）。使用评分分析进行IHC估计。探讨GLUT-1/VEGF表达/病理肿瘤长度（p-tumor length）与最大标准摄取值（SUV max）的相关性，以及GLUT-1/VEGF表达/SUV max与病理T（p-T）分期、淋巴结转移（p-N）分期的关系。结果如下：SUV max与GLUT-1表达和p肿瘤长度显著相关[GLUT-1：r=0.475，p &lt; 0.001，p肿瘤长度：r=0.475，p &lt;0.001]。原发肿瘤的SUV max与p-T分期、p-N分期和VEGF表达显著相关[p-T分期：p &lt;0.001，p-N分期：p=0.037，VEGF表达：p=0.009]。GLUT-1表达与p-T分期/VEGF表达之间有统计学显著差异，但与p-N分期之间无统计学显著差异（p-T分期：p = 0.012，VEGF表达：p=0.01，p-N分期：p=0.572）。VEGF表达与p-T分期有显著相关性（p=0.032），与p-N分期无显著相关性（p=0.763）。结论：GLUT-1和VEGF可作为18F-FDG摄取的指标。SUVmax与肿瘤进展及淋巴结转移有关。

To examine the relationship between glucose transporter (GLUT-1) and vasoendothelial growth factor (VEGF) expression and fluorine-18-fluorodeoxyglucose (^<18>F-FDG) uptake in esophageal squamous cell cancer (ESCC) patients. Methods : Fifty-seven patients were included in this study. The patients consisted of 52 males and 5 females. ^<18>F-FDG positron emission tomography/computed tomography (PET)/CT was performed prior to the surgery. Immunohistochemistry (IHC) was performed using postoperative histopathological specimens. The estimation of IHC was conducted using scoring analysis. We investigated the correlations between maximum standardized uptake value (SUV max) and GLUT-1/VEGF expressions/pathological tumor length (p-tumor length), and the relationships between pathological T (p-T) stage and GLUT-1/VEGF expressions/SUV max and between lymph node metastasis (p-N) stage and GLUT-1/VEGF expressions/SUV max. Results : SUV max were significantly correlated with GLUT-1 expressions and p-tumor length [GLUT-1 : r=0.475, p < 0.001, p-tumor length : r=0.475, p <0.001]. SUV max of the primary tumor had a significant relationship with p-T stage, p-N stage, and VEGF expression [p-T stage : p <0.001, p-N stage : p=0.037, VEGF expression : p=0.009]. There was a statistically significant difference between GLUT-1 expression and p-T stage/VEGF expression but not p-N stage (p-T stage : p=0.012, VEGF expression : p=0.01, p-N stage : p=0.572). VEGF expression had a significant relationship with p-T stage but not p-N stage (p-T stage : p=0.032, p-N stage : p=0.763). Conclusion : Our data indicate that 18F-FDG uptake can be determined by GLUT-1and VEGF. SUV max would have a connection with the tumor progression and lymph node metastasis.