Cellular characteristics and clinical assessment of breast cancer using F-18 FDG-PET

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One hundred eighteen female patients (age range 28-91 years) with 122 lesions suspected of having breast cancer underwent fluorine-18 fluorodeoxyglucose (^<18>F-FDG) PET for preoperative staging. After the whole-body image was acquired, prone breast PET imaging was performed. The findings from both images were compared with the histopathologic results. Sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and accuracy were used to compare the diagnostic accuracy of prone breast PET images with that of whole-body PET images. Sensitivity, specificity, PPV, NPV, and accuracy of whole-body PET images were 83%, 50%, 97%, 17%, and 80%, and for prone breast PET images were 95%, 50%, 96%, 43%, and 93%. Ten of 114 breast cancerous lesions (8.8%) were detected on prone breast PET images alone. There was statistical difference between the sensitivity, accuracy, and NPV of prone breast PET images and, those of whole-body PET images (P < 0.0001 for sensitivity and accuracy, and P < 0.0009 for NPV). In conclusion, our data regarding the 122 lesions suspected of breast cancer with regard to the usefulness of prone breast PET imaging indicate that prone breast PET images are effective in detecting breast cancer.With respect to cell proliferation in breast cancer, we evaluated the relationship between ERK MAPK and SUVmax obtained by FDG-PET. Unfortunately, there was no correlation between ERK MAPK obtained by immunohistopathology and SUVmax. Our resultant data addressed that cell proliferation in breast cancer is need to choose the future course in the FDG-PET study.