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Cellular characteristics and clinical assessment of breast cancer using F-18 FDG-PET

使用 F-18 FDG-PET 进行乳腺癌的细胞特征和临床评估

基本信息

批准号：
17591304
负责人：
ISHIBASHI Masatoshi
金额：
$ 1.35万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591304/
关键词：
Breast cancer Cell proliferation ERK MAPK Prognosis of patients with breast cancer

项目摘要

One hundred eighteen female patients (age range 28-91 years) with 122 lesions suspected of having breast cancer underwent fluorine-18 fluorodeoxyglucose (^<18>F-FDG) PET for preoperative staging. After the whole-body image was acquired, prone breast PET imaging was performed. The findings from both images were compared with the histopathologic results. Sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and accuracy were used to compare the diagnostic accuracy of prone breast PET images with that of whole-body PET images. Sensitivity, specificity, PPV, NPV, and accuracy of whole-body PET images were 83%, 50%, 97%, 17%, and 80%, and for prone breast PET images were 95%, 50%, 96%, 43%, and 93%. Ten of 114 breast cancerous lesions (8.8%) were detected on prone breast PET images alone. There was statistical difference between the sensitivity, accuracy, and NPV of prone breast PET images and, those of whole-body PET images (P < 0.0001 for sensitivity and accuracy, and P < 0.0009 for NPV). In conclusion, our data regarding the 122 lesions suspected of breast cancer with regard to the usefulness of prone breast PET imaging indicate that prone breast PET images are effective in detecting breast cancer.With respect to cell proliferation in breast cancer, we evaluated the relationship between ERK MAPK and SUVmax obtained by FDG-PET. Unfortunately, there was no correlation between ERK MAPK obtained by immunohistopathology and SUVmax. Our resultant data addressed that cell proliferation in breast cancer is need to choose the future course in the FDG-PET study.

具有122处疑似乳腺癌病变的118名女性患者(年龄范围28-91岁)接受氟-18氟脱氧葡萄糖(^ 18 F-FDG)PET用于术前分期。获得全身图像后，进行俯卧位乳腺PET成像。将两张图像的结果与组织病理学结果进行比较。使用敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性来比较俯卧乳腺 PET 图像与全身 PET 图像的诊断准确性。全身 PET 图像的敏感性、特异性、PPV、NPV 和准确性分别为 83%、50%、97%、17% 和 80%，俯卧乳腺 PET 图像的准确性分别为 95%、50%、96%、43% 和 93%。仅在俯卧位乳房 PET 图像上就检测到了 114 个乳腺癌病变中的 10 个（8.8%）。俯卧位乳腺 PET 图像与全身 PET 图像的灵敏度、准确性和 NPV 之间存在统计学差异（灵敏度和准确性 P < 0.0001，NPV P < 0.0009）。总之，我们对 122 个疑似乳腺癌病灶的俯卧位乳腺 PET 成像的有用性数据表明，俯卧位乳腺 PET 图像可有效检测乳腺癌。关于乳腺癌细胞增殖，我们评估了 FDG-PET 获得的 ERK MAPK 与 SUVmax 之间的关系。不幸的是，免疫组织病理学获得的ERK MAPK 与SUVmax 之间没有相关性。我们的结果数据表明，乳腺癌细胞增殖需要选择 FDG-PET 研究的未来方向。