The treatment of liver cirrhosis by transplantation of the hepatic progenitor cells with transformation

本研究的目的之一是评估BMP7的有效性。BMP7是一种tgf - β抑制剂，tgf - β是肝硬化的关键分子之一。我们制作了BMP7表达质粒载体，用CCl4诱导肝硬化模型进行转染。然而，在小鼠肝硬化模型中，BMP7转染组和未转染组的HE染色、马松三色染色（MT染色）和RT-PCR检测1a胶原基因表达的结果并无差异。根据这些结果，我们无法证明BMP7治疗肝硬化的有效性。

One of the purpose of this study was to evaluate the effectiveness of BMP7. BMP7 is an inhibitor of TGF-beta which is one of the key moleclue of liver cirrhosis. We made BMP7 expressing plasmid vector, and perfomed transfection using a model of liver cirrhosis induced by CCl4.Howerver, the findings of the liver cirrhosis showed by HE staining, Masson Trichrome staining (MT staining), and RT-PCR for collagen 1a gene expression were not different between the group with BMP7 tarnsfection and without BMP7 transfection in the mouse liver cirrhosis model. With these results, we could not show the effectiveness of BMP7 in the treatment of liver cirrhosis.