Nuclear matrix associating factors, Satb, are novel regulators of murine placentation

我们发现了新的滋养层细胞分化调节因子Satb1和Satb2。它们被称为核基质缔合分子。Satb1和Satb2是维持啮齿动物滋养层细胞在干细胞条件下所必需的。我们还发现Eome是Satb1和Satb2的靶基因。EOMES是众所周知的滋养层干细胞维持所必需的调节因子。因此，Satb1和Satb2上调Eome的表达，以阻止滋养层细胞分化。我们以论文形式发表了这些结果(Asanoma等人，2012年)。

We identified novel regulators of trophoblast cell differentiation, Satb1 and Satb2. They had been known as nuclear matrix associating molecules. Satb1 and Satb2 are necessary to maintain rodent trophoblast cells at stem cell condition. We also discovered Eomes as a target gene of Satb1 and Satb2. Eomes is a well-known regulator necessary for maintenance of trophoblast stem cells. Therefore, Satb1 and Satb2 upregulate Eomes expression to keep trophoblast cells from differentiation. We published these results as a paper (Asanoma et al., 2012).