Prediction and prevention of preeclampsia

我们调查了母亲吸烟对胎盘早期血管生成和氧化应激相关基因表达的影响。结果，我们发现在怀孕10-11周的吸烟妇女胎盘中VEGFA的表达较高。吸烟妇女在怀孕早期增加VEGFA的表达可能有助于降低患先兆子痫的风险。接下来，我们研究了抗氧化剂补充对低抗氧化状态妇女的好处。从8-12周开始，每天服用抗氧化剂或对照饮食的低抗氧化状态孕妇。110名妇女随机分为补充组(n=52)和对照组(n=58)。子痫前期发生率：补充组为2.0%，对照组为14.5%，差异有统计学意义(P=0.034)。我们发现，在怀孕早期补充抗氧化剂可能会降低先兆子痫的风险。

We investigated the influence of maternal smoking on the early placental expression of genes related to angiogenesis and oxidative stress. As a result, we revealed that VEGFA placental expression was higher in smoking women at 10-11 weeks of gestation. Increased VEGFA expression in the early stages of pregnancy in smoking women might contribute to the decreased risk of developing preeclampsia.Next, we investigated the benefit of antioxidant supplementation in a cohort of women with low antioxidant status.Pregnant women who had low antioxidant status treated with either antioxidants or control diets daily from 8-12 weeks. 110 women were enrolled, randomly assigned to the supplementation (n = 52) and control group (n = 58). There were significant differences (P=0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% and 14.5%, respectively). We revealed supplementation of antioxidants during early gestation might reduce the risk of pre-eclampsia.