Significance of RCAS1 as targeted molecular therapy in fibrosis and the canceration of the endometriosis

子宫内膜异位症可以影响妇女的一生，包括盆腔疼痛、不孕、异常妊娠和卵巢癌。本研究的目的是为阐明子宫内膜异位症相关疼痛和癌变的分子机制提供线索。我们研究了RCAS1受体结合癌抗原在SiSo细胞上表达）作为将来治疗子宫内膜异位症的有益靶分子。腹水中RCAS1的高浓度水平显示在rAFS（修订的美国生育学会）分类IV期的情况下。在胶原凝胶收缩试验中，RCAS1明显引起凝胶表面面积的显著减小。尽管其假定的机制尚未确定，但这项研究表明RCAS1可能参与了纤维化相关的纤维化。对RCAS1生物学功能的进一步探索将有助于开发不依赖雌激素的子宫内膜异位症新的治疗策略。

Endometriosis can affect a woman's whole life, in terms of pelvic pain, infertility, abnormal pregnancy and ovarian cancer. The aim of this study is to provide a clue to elucidate the molecular mechanisms underling the endometriosis related pain and canceration. We have investigated RCAS1 receptor-binding cancer antigen expressed on SiSo cells) as a beneficial target molecule for the treatment of endometriosis in the future. High level of RCAS1 concentration in ascites was revealed in the case of rAFS (Revised American Fertility Society) classification stage IV. In the collagen gel contraction assay, RCAS1 clearly caused significantly decrease the areas of gel surface. Although its putative mechanisms remain undefined, this research suggested a possibility that RCAS1 is involved in endometriosis-associated fibrosis. Further exploration of RCAS1 biological function will facilitate development of novel therapeutic strategies for endometriosis that does not depend on estrogen.