Novel cancer therapeutic strategies to target RCAS1

针对 RCAS1 的新型癌症治疗策略

• 批准号: 21592134
• 负责人: SONODA Kenzo
• 金额: $ 3万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592134/
• 关键词: RCAS1; リンパ球アポトーシス; 腫瘍間質組織; 血管新生; ectodomain shedding; 悪性腫瘍; 治療標的分子; RNA干渉; 腫瘍間質組; ビメンチン

RCAS1 can induce apoptosis in immune cells including peripheral lymphocytes and natural killer cells after converted to a secreted type by ectodomain shedding. Because RCAS1 not only helps tumor cells to evade immune surveillance but also induces cancer stromal tissue remodeling, RCAS1 is believed to exaggerate aggressive characteristics of human malignancies. Clinically, RCAS1 expression correlates with several pathological variables including tumor size, stage, invasion depth, and lymph node metastasis and is a negative predictor of overall survival in 15 different kinds of cancer. Novel therapeutic strategies against cancer are now under development by targeting an intriguing biomarker RCAS1.

RCAS1通过胞外域脱落转化为分泌型后，可诱导外周血淋巴细胞和自然杀伤细胞等免疫细胞凋亡。由于RCAS1不仅帮助肿瘤细胞逃避免疫监视，而且还诱导癌症间质组织重塑，因此RCAS1被认为夸大了人类恶性肿瘤的侵袭性特征。临床上，RCAS1表达与几个病理变量相关，包括肿瘤大小、分期、浸润深度和淋巴结转移，并且是15种不同类型癌症总生存率的负预测因子。针对癌症的新型治疗策略正在开发中，其靶向是一种有趣的生物标志物RCAS1。

项目成果

Shingo Miyamoto, Manabu Nakashima, Norio Wake. Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding

宫本真吾、中岛学、醒纪男。

• 发表时间: 2010
• 期刊: Experimental Cell Research
• 影响因子: 3.7
• 作者: 三橋暁;他;Kazuko Yamazaki;Kenzo Sonoda
• 通讯作者: Kenzo Sonoda

Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers

• DOI: 10.1111/j.1349-7006.2010.01543.x
• 发表时间: 2010-06-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Ohgami, Tatsuhiro;Kato, Kiyoko;Wake, Norio
• 通讯作者: Wake, Norio

Carcinoma of the uterine cervix : Counter point

宫颈癌：对立点

• 发表时间: 2010
• 期刊: Patient surveillance after cancer treatment (in press)
• 作者: Sonoda K;et al.
• 通讯作者: et al.

RCAS1のshedding分泌機構におけるkey protease同定解析

RCAS1脱落分泌机制关键蛋白酶鉴定分析

• 发表时间: 2009
• 作者: 園田顕三;宮本新吾;小林裕明;和氣徳夫
• 通讯作者: 和氣徳夫

Koichiro Abe, Shingo Baba, Masayuki Sasaki, Tsunehisa Kaku, Norio Wake

阿部光一郎、马场真吾、佐佐木雅之、加来常久、醒纪夫

• 发表时间: 2010
• 期刊: Sentinel node detection with 99mTc phytate alone is satisfactory for cervical cancer patients undergoing radical hysterectomy and pelvic lymphadenectomy. International Journal of Clinical Oncology.
• 作者: Shinji Ogawa;Hiroaki Kobayashi;Satoshi Amada;Hideaki Yahata;Kenzo Sonoda
• 通讯作者: Kenzo Sonoda