Antidepressant and vestibular plasticity

本实验观察了长期应用抗抑郁药对豚鼠前庭系统的影响。在海马区，磷酸化CREB样免疫反应，而在前庭系统，没有发现免疫反应。在海马区，而不是在前庭系统中，BDNF mRNA水平在抗抑郁药组比非抗抑郁药组有统计学意义。右侧半规管切断后24小时，我们研究了前庭系统中的BDNF和trkB mRNA。在前庭神经节细胞中，抗抑郁药组损伤侧的BDNF mRNA和trkB mRNA水平显著高于非抗抑郁药组完整侧。在前庭神经核中，抗抑郁药组损伤侧的BDNF mRNA水平显著高于非抗抑郁药组的健侧。

We investigated the effects of chronic application of antidepressant on the vestibular system in guinea pigs. In the hippocampal region, phosphorylated CREB-like immunoreactivities were observed, while, in the vestibular system, no immunoreactivities were found. We evaluated BDNF mRNA. In the hippocampal region, not in the vestibular system, BDNF mRNA level was statistically higher in the antidepressant group than that in the non-antidepressant group. Twenty-four hours after right lateral semicircular canal transection, we investigated BDNF and trkB mRNA in the vestibular system. In the vestibular ganglion cells, BDNF mRNA and trkB mRNA levels of the lesioned side in the antidepressant group were statistically higher than that of the intact side in the non-antidepressant group. In the vestibular nuclei, BDNF mRNA level of the lesioned side in the antidepressant group was statistically higher than that of the intact side in the non-antidepressant group.