The effects of TGFalpha in intractable sinusitis and new treatment

嗜酸性粒细胞性慢性鼻窦炎（ECRS）被认为是一种难治性和难治性疾病，具有粘稠的粘液产生，长期鼻塞，嗅觉丧失。在这项研究中，我们研究了哪种生长因子在ECRS中深层参与了粘蛋白的过量产生。与正常患者和非嗜酸性CRS患者相比，发现ECRS患者粘膜下组织的tgf - α免疫反应性明显增加。tgf - α通过ERK信号通路与tnf - α协同上调人上皮细胞MUC5AC的表达。我们的研究结果表明，tgf - α在ECRS患者的上气道中高度表达，并与粘液分泌过多密切相关。

Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease with thick mucus production, long-term nasal congestion, loss of sense of smell. In this study, we investigated which growth factor is deeply involved in the mucin overproduction in ECRS.TGF-alpha immunoreactivity was found markedly increased in the submucosal tissue in the ECRS patient compared with that of a normal patient and with noneosinophilic CRS. TGF-alpha synergized with TNF-alpha to upregulate MUC5AC expression in human epithelial cells through the ERK signaling pathway.Our results demonstrated that TGF-alpha was highly expressed in the upper airway tract in ECRS patients and is deeply involved in mucus hypersecretion.