Establishment of new concepts in cone electroretinogram using transgenic rabbits

本研究的目的是确定视紫红质Pro347Leu转基因(TG)兔视锥细胞和感光后神经元对明视ERG a波的贡献。玻璃体内注射CNQX和APB可完全抑制光感受器后神经功能。我们发现，在野生型(WT)兔中，视锥感受器对明视ERGa波的贡献率在54%到75%之间。相比之下，TG兔视锥感光细胞的贡献率在32%到51%之间。这些结果表明，在遗传性光感受器变性的视网膜中，视锥感光细胞对明视ERG a波的相对贡献较小。

The purpose of this study was to determine the contributions of cones and post- photoreceptoral neurons to the a-wave of the photopic ERGs in rhodopsin Pro347Leu transgenic (Tg) rabbits. Post-photoreceptral neural function was completely suppressed by intravitreal injections of CNQX and APB. We found that the percentage contribution of the cone photoreceptorsto the photopic ERG a-waves ranged from 54% to 75% in wild-type (WT) rabbits. In contrast, the percentage contribution of the cone photoreceptors in Tg rabbits ranged from 32% to 51%. These results suggest that the relative contribution of cone photoreceptors to the photopic ERG a-wave is smaller in retinas with inherited photoreceptor degeneration.