New therapy for malignant salivary gland tumor by targeting the hormone receptor

孕酮(PG)与乳腺的发育密切相关。此外，PG被认为在乳腺癌的进展中起着作用。然而，关于它在SGT中的作用，人们知之甚少。在这项研究中，我们使用了从唾液腺建立的人腺样囊性癌细胞株ACCM，以阐明孕激素受体(PR)对细胞增殖的作用。在PR缺乏的侵袭性ACCM细胞中，PG对细胞增殖无影响。但将PR导入ACCM细胞后，PG明显抑制细胞的增殖活性。这种抑制细胞增殖的作用伴随着p21的上调和Id1、c-myc的下调。此外，经PG处理的PR转染体表现出明显的形态变化。我们的结果提示PR再导入疗法可能是抑制人类SGT进展的一种可行的方法。

Progesterone (Pg) is intimately involved in the development of the mammary gland. Further, it is believed that Pg plays a role in breast cancer progression. However, little is known regarding its role in SGTs. In this study, we used ACCM, a human adenoid cystic carcinoma cell line established from the salivary gland, in order to clarify the role of the progesterone receptor (PR) on cell proliferation. No effect of Pg on cell proliferation was observed in the PR-deficient aggressive ACCM cells. However, after introducing PR into the ACCM cells, Pg markedly inhibited the proliferative activity of the cells. This inhibitory effect on cell proliferation was accompanied by p21 upregulation and Id1, c-myc downregulation. Moreover, Pg-treated PR transfectants showed significant morphological change. Our results suggested that PR reintroduction therapy might be a viable method of inhibiting human SGT progression.