Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.

机械应力与成骨的关系已被广泛研究。然而，骨膜在机械应力下骨重建中的作用却知之甚少。我们假设骨膜感受到机械应力而导致骨重建，因此，我们对骨膜细胞进行了机械拉伸实验，并对它们的基因表达谱进行了表征，发现骨膜细胞在拉伸刺激下诱导WNT通路和BMP通路的基因表达变化，这两条通路共同促进成骨细胞的分化和成骨。我们的研究结果还表明，在机械应力诱导的骨重建在体内，骨膜感觉到机械应力，以控制信号，促进成骨细胞分化和成骨。

The relationship between mechanical stress and osteogenesis has been widely studied. However, little is known about the functions of the periosteum in bone remodeling under mechanical stress. We hypothesized that the periosteum senses a mechanical stress to induce bone remodeling, therefore, we subjected periosteum cells to load mechanical stretching and characterized their gene expression profiles.Periosteum cells appear to induce, in response to the stretch stimulus, gene expression changes in WNT pathway and BMP pathway, which cooperate to promote osteoblast differentiation and osteogenesis. Our results also suggest that during mechanical stress-induced bone remodeling in the body, the periosterum senses the mechanical stress to control signals for promoting osteoblast differentiation and osteogenesis.