Function of immunocompetent cells in the tension zone of periodontal ligament in tooth movement

正畸牙齿移动过程中牙周韧带张力区的组织反应被简化为牙周韧带纤维的牵拉和骨的形成。然而，PDL纤维在张力区被强迫进行强烈的牵拉，从而导致防御系统的介入。我们用组织学和免疫组织化学方法研究了牙齿移动早期免疫系统在牙周韧带张力区的参与情况。牙齿移动开始后6h，牙周间隙扩大到130%以上，牙周韧带纤维表现出较强的牵引性。ED1阳性细胞(巨噬细胞和单核细胞)增多。然而，成纤维细胞也有IL-1B和MMP12的定位。这表明成纤维细胞参与了牙周膜的防御反应，在张力区牙周反应的早期阶段，牙周膜重排和牙槽骨上的骨形成之前就有成纤维细胞参与。

Tissue reaction of the tension zone of periodontal ligament ( PDL ) during orthodontic tooth movement has been simplified as tugging of PDL fibers and bone formation. However, PDL fibers in the tension zone are forced to strong tugging, which causes involvement of defense system. We examined an involvement of immune system in the tension zone of PDL in early stage of tooth movement, using histological and immunohistochemical methods. Periodontal space was enlarged to more than 130 % and the PDL fibers showed a strong tugging aspect 6 hours after initiation of tooth movement. ED1 positive cells ( macrophage and monocyte ) were increased. However, fibroblasts also showed localization of IL-1B and MMP12. This indicats that fibroblasts involve in defense reaction of the PDL, prior to rearrangement of the PDL and bone formation on the alveolar bone in the very early stage of periodontal reaction in the tension zone.