Mechanobiology of Cell Interaction using Optical Tweezers

快速构建过程是将大量细胞模块构建成三维(3D)组织所必需的，这些组织保留了细胞的组织几何形状和初始条件。我们提出了一种新的三维组装技术，利用水转移打印来制造中空管状组织结构。利用这种组装技术，我们讨论了凝胶基质的3D转录体与转移组织的发育形状之间的关系，从而构建了一个中空的管状组织。对组织正常发育和功能的3D环境的模拟对于设计可用于形成复杂组织的体外模型至关重要。这些人工中空管组织可作为药物疗效评价和手术训练的体外模拟器。

A rapid construction process is necessary for building up numerous cell modules into three-dimensional (3D) tissues that retain the tissue geometries and initial conditions of the cells. We proposed a new 3D assembly technique using water transfer printing to fabricate a hollow tubular tissue structure. By utilizing this assembly technique, we discuss the relationship between the 3D transcriptional body of a gel matrix and the developed shape of transferred tissue, and then fabricate a hollow tubular tissue. Simulation of the 3D environment in which tissues normally develop and function is crucial for the engineering of in vitro models that can be used for the formation of complex tissues. These artificial hollow tubular tissues could be used as in vitro simulators for drug efficiency evaluation and operative training.