Investigation of the interaction between organic nanocrystals and blood serum for the development of the organic nanocrystal-based drug delivery system

在这个项目中，我们成功地制备了几种荧光有机纳米晶体，它们的粒径在十分之一纳米到一微米之间。我们发现多种类型的有机纳米晶体被发现溶解在血清成分中，从而显示出分子荧光。这种现象只在纳米晶体状态下观察到，而在块状晶体中没有。这意味着有机纳米晶体能够全身给药，因为它们在血清成分中的溶解度。电泳分析将不断揭示有机纳米晶体与血清组分相互作用的详细信息。从纳米晶给药模型动物的角度来看，高效液相色谱分析显示药物和染料对眼部等器官的渗透增强。我们认为使用有机纳米晶体是新型药物传递系统的候选材料。

In this project, we succeeded in preparing several kinds of fluorescent organic nanocrystals with the particle size around several tenth nanometers to one micron meter. We found that numerous types of organic nanocrystals were revealed to be dissolved in serum component, resulting in showing molecular fluorescence. This phenomenon was only observed in the state of nanocrystals, but not in bulk crystals. This means that the organic nanocrystals are able to take systemic administration because of their solubility in the serum components. The detailed information of the interaction between organic nanocrystals and serum component by electrophoresis analysis will be revealed continuously. In the viewpoint of nanocrystal administration into model animals, the enhanced penetration of drug and dye into organ such as ocular was revealed by HPLC analysis. We believe that the using organic nanocrystals are candidate for the new class of drug delivery system.