Bio-related chemistry of N-confused porphyrinoids

类卟啉化合物（类卟啉大环化合物）因其独特的性质而引起人们的广泛关注。由于卟啉类化合物在生物学中的重要性，人们对卟啉类化合物在生物相关研究中的应用进行了展望。我们成功地合成了N-混乱卟啉（NCP）和N-稠合卟啉（NFP）的水溶性衍生物，这使我们能够探索在水介质中与生物分子的相互作用。使用这些衍生物，实现了生物硫醇的光学传感和G-四链体DNA结构的调节。

Porphyrinoids (porphyrin-like macrocycles) have attracted considerable attention for their properties. Because of the importance of porphyrins in biology, utilization of porphyrinoids in the bio-related research is anticipated. We have succeeded in synthesizing water-soluble derivatives of N-confused porphyrin (NCP) and N-fused porphyrin (NFP), which enabled us to explore the interactions with biomolecules in aqueous media. Using these derivatives, optical sensing of biothiols and modulation of G-quadruplex DNA structures were achieved.