Integration of a treatment with a device and regenerative medicine . an treatment of brain aneurysm with platinum coils is presented as an example -

据报道，涂覆有某些种类的蛋白质（如生长因子）的栓塞弹簧圈可有效预防栓塞动脉瘤的再通。然而，这些弹簧圈难以灭菌且不稳定，因此，不容易获得批准。该项目的目的是通过开发一种新型脑动脉瘤治疗器械，将器械治疗与再生医学相结合，该器械结合了传统栓塞弹簧圈和低分子量药物，并成功使用了药物洗脱支架。在该项目中，他汀类药物，这是治疗高胆固醇血症的药物，被选为低分子量药物。尝试在线圈表面上形成磷脂层，将染色剂结合到这些层中，并从结合层中连续释放他汀类药物。同时对荧光显微镜、表面等离子体共振、表面等离子体场增强荧光和细胞培养进行了分析。从这些评估中获得了关于他汀类药物从磷脂层缀合和连续释放的有益信息，并组成了含有与他汀类药物缀合的磷脂层的线圈。预期这些弹簧圈具有作为动脉瘤栓塞弹簧圈的高潜力。

It has been reported that embolization coils coated with some kinds of proteins, such as growth factors, are effective in the prevention of recanalization in embolized aneurysms. These coils are, however, difficult to be sterilized and unstable, therefore, not assumed to be approved easily. The aim of this project is integration of a treatment with a device and regenerative medicine via the development of a novel device for a therapy of brain aneurysms which combined conventional embolization coils and low-molecular-weight drugs, following a succeeded example, drug eluting stent. In this project, statins, which were drugs for the treatment of hypercholesterolemia, were selected as low-molecular-weight drugs. Formation of phospholipid layers onto coil surfaces, conjugation of stains into these layers and continuous release of statins from the conjugated layer were tried. The feasibility of analyses using a fluorescent microscope, surface plasmon resonance, surface plasmon field-enhanced fluorescent and cell culture were also assessed. Beneficial information for conjugation and continuous release of statins from the phospholipid layer for was obtained from these assessments and coils containing phospholipid layer conjugated with statins were composed. These coils were expected to have a high potential as embolization coils for aneurysms.