The integrated search of mesenchymal stem cell fate determination of differentiation controlled by micro RNAs

在这项研究中，我们发现了一个受转录因子osterix转录调控的microRNA，它在成骨细胞分化中起着关键作用。我们发现这种微RNA靶向促进成骨细胞分化并抑制其功能的基因，并且这种微RNA本身的转录受到成骨细胞的负调控。此外，我们还发现这种微RNA负向调控成骨细胞分化。因此，在本研究中，我们发现了一种能够调控间充质干细胞分化成骨细胞命运的微RNA。这一发现有助于进一步了解微rna对骨质疏松、肥胖等生活方式疾病的致病机制。

In this study, we identified a microRNA which are transcriptionally regulated by the transcription factor osterix that have critical roles for osteoblast differentiation. We identified that this micro RNA targets the genes which promote osteoblast differentiation and inhibit their function, and transcription of this micro RNA itself is negatively regulated by osterix. Moreover, we also found that this micro RNA negatively regulates osteoblast differentiation. Therefore, in this study we found a micro RNA that could regulate the fate of mesenchymal stem cells for osteoblast differentiation. This finding further contributes the understanding of pathogenic mechanisms with micro RNAs to the life-style diseases such as osteoporosis and obesity.