Clinical application of genetic tests regarding cariogenicity of Streptococcus mutans

一个重要的毒力因子。变形葡聚糖是从蔗糖合成水不溶性葡聚糖（WIG）的葡糖基转移酶。我们对S. gtfB基因编码的GtfB具有两个功能域。GtfB的羧基末端部分称为葡聚糖结合结构域，由直接重复单元编码。本研究结果表明，重复单元中第33位氨基酸Gly被Ser取代与S合成WIG有关。变异人我们发现，p.G33S替代与龋齿的发展在1年的学生使用含氟漱口水。

An important virulence factor of S. mutans is a glucosyltransferase synthesizing water-insoluble glucan (WIG) from sucrose. We performed sequencing of the gtfB gene of S. mutans isolates derived from primary school students.GtfB coded by gtfB gene possess two functional domain. The carboxyl-terminal portion of GtfB is called the glucan binding domain and is coded by the direct repeating units. The results of this study indicated that the substitution of 33rd amino acid Gly to Ser in the repeating unit is associated with WIG synthesis by S. mutans. And we revealed that the p.G33S substitution is associated with caries development in 1 year in the students using a fluoride mouth rinse.