Sesquiterpenoide und andere biologisch aktive Marker-Verbindungen in bulgarischen Achillea-millefolium-Arten

本项目的目的是对保加利亚民间医药中使用的小叶木兰属植物进行比较植物化学研究，以确定主要的生物活性成分，并阐明未知化合物的结构。特别关注倍半萜内酯，因为它们被认为是纱线中的活性成分。含有内酯的馏分将使用现代色谱技术进行分离，并将通过光谱方法对单独的化合物进行表征。还将从化学和生物学的角度对植物总提取物中极性较低的部分进行调查。推荐种植含丙唑烯含量最高、生物活性显着的植物品种。

The purpose of this project is a comparative phytochemical study of the Bulgarian plant species of Achillea millefolium group (yarrow) used in folk medicine, with the view of identifying the main biologically active components and elucidating the structure of the unknown compounds. A special attention will be paid on the sesquiterpene lactones, as they are recognized to be the active principles in yarrow. The lactone-containing fractions will be submitted to separation using modern chromatographic techniques, and the individual compounds will be characterized by spectroscopic methods. The less polar fractions of the total plant extracts will be also investigated from both chemical and biological point of view. The plant species with the highest content of proazulenes and significant biological activity will be recommended for cultivation.