Analysis of a novel signaling network that regulates cell growth and division

我们之前已经证明，IQGAP3是一种细胞内信号分子，由于其调节Ras（一种原癌基因产物）的能力，它负责细胞增殖。在本研究中，我们发现IQGAP3也直接参与细胞质分裂过程，并探讨了其潜在的分子机制。此外，我们还研究了与细胞增殖状态密切相关的IQGAP3基因的表达，以及IQGAP3调控Ras的分子机制。

We have previously shown that IQGAP3, an intracellular signaling molecule, is responsible for cell proliferation because of its ability to regulate Ras, a proto-oncogene product. In the present study, we showed that IQGAP3 is directly involved in the process of cytokinesis as well, and the underlying molecular mechanisms were also addressed. In addition, expression of the IQGAP3 gene, which is tightly co-related with the state of cell proliferation, as well as the molecular mechanismswith which IQGAP3 regulates Ras, was also investigated.