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Spatial regulation of branching tubulogenesis by Wnt signaling

Spatial regulation of branching tubulogenesis by Wnt signaling
Wnt 信号传导对分支管发生的空间调控
批准号:
23790333
负责人:
MATSUMOTO Shinji
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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相关文献

中文摘要
翻译
通过基因芯片分析鉴定了调控Wnt3a和EGF诱导的上皮细胞分支小管形成的新因子X。因子X分别激活Rac和抑制Rho,导致细胞伸展和激活细胞运动。细胞形态改变诱导细胞在三维基质中增殖。这些结果表明,Wnt和EGF信号协同调控上皮细胞分支小管的形成。
英文摘要
Novel factor X regulating epithelial branching tubulogenesis induced by Wnt3a and EGF was identified by microarray analysis. Factor X activated Rac and inhibited Rho respectively, resulting in cell extension and ac tivation of cell motility. Cell morphological change induced cell proliferation in three dimensional matrix. These results indicate that Wnt and EGF signaling regulates epithelial branching tubulogenesis cooperatively.
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会议论文
Wnt3a and Wnt5a regulate epithelial polarity and tubulogenesis cooperatively
Wnt3a 和 Wnt5a 协同调节上皮极性和肾小管发生
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Matsumoto, S., Kikuchi, A.]
通讯作者: A.
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [古賀宣勝, 松村保広]
通讯作者: 松村保広
DOI: 10.1038/ncomms1861
发表时间: 2012-05-01
期刊: NATURE COMMUNICATIONS
影响因子: 16.6
作者: [Ishida-Takagishi, Maki, Enomoto, Atsushi, Takahashi, Masahide]
通讯作者: Takahashi, Masahide
Wnt/β-cateninシグナルとEGFシグナルの協調による三次元基質内での上皮分枝管腔形成制御機構の解析
Wnt/β-catenin信号和EGF信号协调分析三维矩阵内上皮分支管腔形成的控制机制
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kikuchi A, Yamamoto H, Sato A, Mastumoto S., 松本 真司, Nakagawa T, 松本 真司]
通讯作者: 松本 真司
共 11 条
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