Innate immunity involved in the onset of Henoch-Schoenlein purpura and nephritis

我们推测先天免疫可能参与了过敏性紫癜（Henoch-Schoenlein purpura，HSP）的发病过程，尤其是NF-κB活化抑制因子A20表达的改变可能是继发性肾炎和HSP病情加重的重要因素。本研究通过定量RT-PCR和流式细胞术检测淋巴细胞表面表达，分析A20在HSP中的作用。结果表明，HSP患者与正常对照组在LPS刺激后A20定量RT-PCR及PBMNCs的表达存在差异，而HSP伴肾炎组与不伴肾炎组之间差异无统计学意义。另一方面，在肾炎的危险因素中，男性和腹痛患者A20的定量RT-PCR表达较高，这可能意味着A20表达的变化可能影响HSP患者肾炎的发病。

We hypothesize that innate immunity may be involved in the onset of Henoch-Schoenlein purpura(HSP), and especially the variation of A20 expression, which is known as an inhibitor of NF-κB activation, can be the important factor for secondary nephritis and the aggravation of HSP. In this study, we analyzed the role of A20 for HSP by quantitative RT-PCR and flow cytometry of lymphocyte surface expression. The results demonstrated the differences between HSP patients and normal controls in A20 of the quantitative RT-PCR and PBMNCs expression after the stimulation of LPS, but no significant difference between HSP patients with and without nephritis. On the other hand, among the risk factors for nephritis, male and the patients with abdominal pain had high expression of quantitative RT-PCR of A20, which may imply that the variation of A20 expression may affect the onset of nephritis in HSP patients.