Identification of host cell factors relating the replication of respiratory syncytial virus

呼吸道合胞病毒(RSV)是全球儿童呼吸道感染的主要病原体。早产儿患严重和致命性呼吸道合胞病毒感染的风险特别高。由于目前还没有有效的疫苗，迫切需要开发像奥司他韦这样的抗病毒药物来治疗流感病毒。在这项研究中，我们试图利用低感细胞系MDCK和来自敏感细胞的cDNA文库来鉴定与RSV复制有关的宿主细胞因子。结果表明，EPhin-B2、RARRES2和CCL2的表达增加了RSV在MDCK中的复制。在未来，有必要阐明这些分子在RSV复制中的确切作用。

Respiratory syncytial virus (RSV) is a major causative agent of respiratory tract infections in children worldwide. Preterm children are at a particularly high risk of developing severe and lethal RSV infections. Because effective vaccines are not available, it is urgently necessary to develop antivirus drugs like oseltamivir for influenzavirus. In this study, we tried to identify host cell factors relating the replication of RSV using low-susceptible cell line, MDCK, and cDNA library derived from susceptible cells. As the results, expression of Ephrin-B2, RARRES2, and CCL2 increased the replication of RSV in MDCK. In future, it is necessary to clarify precise roles of these molecules in the replication of RSV.