The effects of CCR7 ligands on Th2 chemokine production by mouseLangerhans cells

CCL19和CCL21是趋化因子，在郎格汉斯细胞从皮肤到引流淋巴结的迁移过程中起着关键作用。我们发现CCL19和CCL21促进CCL17的产生，CCL17是一种已知的Th2型趋化因子，表明CCL19和CCL21通过募集Th2细胞来增强LCS介导的Th2型免疫反应。考虑到LCS在包括特应性皮炎在内的炎症性皮肤病的病理生理学中的关键作用，我们的结果可能为此类疾病的趋化因子靶向治疗提供新的见解。

CCL19 and CCL21 are chemokines which are pivotal for Langerhans cells in their migration form the skin to the draining lymph nodes. We found that CCL19 and CCL21 enhance the production of CCL17, which is known to be a Th2-type chemokine, indicating that CCL19 and CCL21 augment the Th2-type immune response mediated by LCs through the recruitment of Th2 cells. Considering the critical roles of LCs in the pathophysiology of inflammatory skin diseases including atopic dermatitis, our results may provide new insights into the chemokine-targeted therapies for such diseases.