Creation of functional mutant interferon-alpha for increase of bioactivity and decease of side-effects

在本研究中，我们重点发现了利用结构突变体治疗干扰素（IFN）的新方法，该方法可以提高干扰素在体内的活性并减少其副作用。我们从IFN突变体文库中获得38个对IFN受体具有不同结合活性的IFNα8突变体进行筛选。在这些突变体中，我们发现4个突变体IFNα8的活性优于野生型IFNα8。在未来，我们将利用这些突变的ifn通过分析其增加活性的机制来创造新的生物制药。

In this study, we focused on lead discovery for new interferon(IFN) therapy using structural mutant, which increase the activity and decrease the side-effects in vivo. We obtained 38 IFNα8 mutants, which have different binding activities for IFN receptor to perform the screening from IFN mutant library. Among these mutants, we found 4 mutant IFNs have superior activities than wild-type IFNα8.In future, we will utilize these mutant IFNs to create a new biopharmaceuticals by analyzing the mechanisms of increasing activity.