The brain regeneration using chemotactic stimulation with favorable chemoattractant factor for autologous tissue stem cells

本项目的目的是利用干细胞从未受损组织向已植入高亲和力支架的受损组织迁移，实现脑组织再生。我们研制了干细胞迁移的化学引诱剂鸡尾酒。我们证实了这种鸡尾酒加速了干细胞的迁移。我们制造了纳米颗粒，可以释放持续42天以上的趋化因子。最后，我们制作脚手架。虽然支架具有适合细胞粘附和生长的孔径，但支架材料对干细胞具有细胞毒性。细胞毒性一直在改善。

The aim of this project is for regeneration of brain tissue using stem cell migration from undamaged tissue to damaged tissue,that has been implanted high affinity scaffold. We made chemoattractant cocktail for stem cell migration. We confirmed that the cocktail accelerated stem cells migration. And we fabricated nano particles, which can release chemotactic factor long lasting, over 42 days. Finally, we fabricated scaffold. Although the scaffold had appropriate pore size for cell adhesion and growing, scaffold materials had cytotoxicity against stem cells. Cytotoxicity has been improving.