Regeneration of growth plate using mesenchymal stem cells

由于骨骺和干骺端之间的全部或部分骨桥，生长板损伤常引起骨缩短或受影响骨的角度畸形。为了探索生长板损伤的治疗新方法，我们研究了滑膜源性间充质干细胞制备的三维人工组织用于损伤生长板再生的可行性。我们的结果表明，物理样软骨组织通过植入三维组织重组。此外，我们证实在组织再生后进行骨缩短或角形畸形的矫正。

Growth plate injuries often cause bone shortening or angular deformities of affected bones because of total or partial bony bridging between epiphysis and metaphysis. In order to explore new method of the treatment of growth plate injuries, we investigated availability of 3-dimentional artificial tissue, which is made of synovium-derived mesenchymal stem cells, for the regeneration of injured growth plate. Our results demonstrated that physis-like cartilage tissue was reorganized by implantation of 3D tissue. Moreover, we confirmed that correction of bone shortening or angular deformities was followed after the regeneration of tissue regeneration.