Histological studies on the relationship between the baroreceptors in the eye and glaucomatous changes

本实验旨在探讨辣椒素敏感感觉神经或瞬时受体电位香草样蛋白1 （TRPV-1）与青光眼病变的关系。青光眼动物模型眼的TRPV-1样免疫反应性与对照大鼠无明显差异。研究了辣椒素去神经的作用。打开眼睑14天后，55 mg/kg辣椒素处理的新生大鼠IOP升高，20 - 42 mmHg。这些眼睛被放大了。目前还不清楚这一结果是否仅仅是由辣椒素去神经作用引起的。这些辣椒素处理的大鼠通过结扎外膜静脉来提高眼压。与正常大鼠青光眼模型无组织学差异。

The purpose of this experiment is to investigate the relationship between capsaicin-sensitive sensory nerve or transient receptor potential vanilloid 1 (TRPV-1) and glaucomatous changes. The eyes of the animal model of glaucoma did not show any difference of TRPV-1 like immunoreactivity from the control rat eyes. The effect of capsaicin denervation was also studied. Fourteen days after eyelids opened, the newborn rat treated with 55 mg/kg capsaicin showed the IOP elevation, 20 - 42 mmHg. These eyes were enlarged. It was unclear if the result was caused only by the effect of capsaicin denervation. These capsaicin treated rats were insulted by the ligation of the episcleral vein to elevate intraocular pressure. The histological difference from normal rat glaucoma model was not detected.