Evaluation of proshodontic treatment on diabetes prevention using incretin as a indicator.

胰高血糖素样肽1（Glucagon-like peptide 1, GLP-1）由小肠分泌到血液中，以响应膳食中葡萄糖的摄入，并刺激胰腺胰岛素的分泌。为了研究咀嚼和与肠促胰岛素分泌相关的餐后血糖之间的关系，我们将正常进食后的血糖水平与年轻健康志愿者以三种指定方式之一进食测试餐后的血糖、血清胰岛素和血浆活性GLP-1浓度的变化进行了比较。2.单侧咀嚼；快速进食，每一口咀嚼3.30次。每组10名志愿者参加。在正常饮食和三种特定饮食方式之间，血糖和胰岛素浓度没有差异。血浆活性GLP-1浓度未因单侧咀嚼或快速进食而改变，但在餐后30分钟，与正常进食相比，每一口咀嚼30次显著增加。

Glucagon-like peptide 1(GLP-1) is secreted from the small intestine to the blood in response to glucose intake during a meal, and it stimulates pancreatic insulin secretion. To investigate the relationship between chewing and postprandial blood glucose related to incretin secretion, we compared the levels following usual eating with the changes of blood glucose, serum insulin, and plasma active GLP-1 concentrations after young healthy volunteers ate a test meal in one of three specified ways : 1.unilateral chewing, 2.quick eating, 3.30 times chewing per one bite. Ten volunteers participated in each group. There were no differences in the blood glucose or insulin concentrations between usual eating and the three specified ways of eating. Plasma active GLP-1 concentration did not change by unilateral chewing or quick eating, but it increased significantly by 30 times chewing per one bite compared with usual eating at 30 minutes after a meal.