The effect of stress-related gene expression on nocturnal parafunction.

应激相关基因表达对夜间功能障碍的影响。

• 批准号: 25670826
• 负责人: HOSOKAWA Ryuji
• 金额: $ 2.41万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670826/
• 关键词: ストレスマーカー; ベンゾジアゼピン; ブラキシズム; パラファンクション; 睡眠; 遺伝子多型; 睡眠時ブラキシズム; 精神的ストレス

Peripheral-type benzodiazepine receptor (PBR) gene polymorphism is associated with stress sensitivity, but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress before and after sleep bruxism. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphism. The PBR gene was amplified after collection of DNA from oral mucosa cells. Polymorphisms were identified by direct sequencing after PBR gene amplification by PCR. We also measured masseter muscle activity during sleep using portable electromyography to evaluate sleep bruxism. The number of bruxism events was significantly higher in the G/A than the G/G group. Changes in salivary CgA levels were significantly lower in the G/A than G/G group.

外周型苯二氮卓受体（PBR）基因多态性与应激敏感性相关，但目前尚不清楚该基因的多态性是否对夜间磨牙症前后的心理应激有任何影响。本研究旨在探讨PBR基因多态性与夜间磨牙症的关系。从口腔粘膜细胞中提取DNA后扩增PBR基因。PCR扩增PBR基因后直接测序鉴定多态性。我们还测量了咬肌活动在睡眠中使用便携式肌电图评估睡眠磨牙症。G/A组的磨牙症事件数量显著高于G/G组。G/A组唾液CgA水平的变化显著低于G/G组。

项目成果

Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms

睡眠磨牙症受外周苯二氮卓受体基因多态性影响

• DOI: 10.1007/s12548-013-0101-z
• 发表时间: 2014
• 期刊: International journal of stomatology & occlusion medicine
• 作者: Takaya Murakami;Chihiro Masaski;Hidetaka Takahashi;Michiko Makino;Taro Mukaibo;Yusuke Kondo;Tetsuji Nakamoto;Ryuji Hosokawa
• 通讯作者: Ryuji Hosokawa