The effect of stress-related gene expression on nocturnal parafunction.

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Peripheral-type benzodiazepine receptor (PBR) gene polymorphism is associated with stress sensitivity, but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress before and after sleep bruxism. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphism. The PBR gene was amplified after collection of DNA from oral mucosa cells. Polymorphisms were identified by direct sequencing after PBR gene amplification by PCR. We also measured masseter muscle activity during sleep using portable electromyography to evaluate sleep bruxism. The number of bruxism events was significantly higher in the G/A than the G/G group. Changes in salivary CgA levels were significantly lower in the G/A than G/G group.