Analysis of cleft palate signal by using CASK knockout mouse
Analysis of cleft palate signal by using CASK knockout mouse
批准号:
23659935
负责人:
YANAGAWA Toru
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
我们假设CASK信号影响腭裂的形成,因为CASK基因敲除小鼠有腭裂。为了阐明该信号,我们通过Q-TOF LC/MS鉴定了与CASK结合的候选分子。我们选择Neurexin作为信号转导分子,然后分析粘附结构域和分子之间的相互作用。此外,分析和评估CASK flox/flox小鼠在腭裂形成中的作用。另一方面,我们发展了一种新的方法,利用小鼠面部畸形来评价形态相似性。
英文摘要
We hypothesize that CASK signal affects cleft palate formation because CASK knock out mouse has cleft palate. To clarify this signal we identified the candidate molecules that associate with CASK by using Q-TOF LC/MS. We selected Neurexin as a signal transduction molecule, then adherent domain and interaction between molecules was analyzed. In addition CASK flox/flox mouse was analyzed and estimated the role of CASK in cleft palate formation. On the other hand we developed a new method which evaluate morphological similarity to use mouse facial deformity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Presurgical nasoalveolar molding orthopedic treatment improves the outcome of primary cheiloplasty of unilateral complete cleft lip and palate, as assessed by naris morphology and cleft gap.
根据鼻孔形态和裂隙评估,术前鼻牙槽成型矫形治疗可改善单侧完全性唇腭裂初次唇整形术的结果。
DOI:
10.1097/scs.0b013e31825196dc
发表时间:
2012
期刊:
Journal of Craniofacial Surgery
影响因子:
0.9
作者:
[Toru Yanagawa, Shizuo Nakane, et.al.]
通讯作者:
et.al.
DOI:
10.1016/j.oooo.2012.01.042
发表时间:
2012-12-01
期刊:
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
影响因子:
2.9
作者:
[Karube, Rei, Sasaki, Hiroyoshi, Bukawa, Hiroki]
通讯作者:
Bukawa, Hiroki
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批准号:15K15730
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2013
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依托单位:
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