Development of novel therapeutic strategies and elucidation of mechanisms regulating allergic inflammation based on circadian rhythms

虽然近年来过敏性疾病急剧增加，但尚未建立有效的治疗方法。本研究的目的是阐明基于昼夜节律调节过敏性炎症的机制，以根据身体的昼夜节律持续缓解过敏的临床体征/症状。通过使用人类特应性皮炎的小鼠模型和狗，检测到过敏性炎症的时间依赖性变化，并且显示出受来自肾上腺的糖皮质激素的控制。这些结果表明，基于昼夜节律的糖皮质激素药物给药可能有效地调节过敏反应。

Although allergic diseases have increased dramatically in recent years, effective therapy has yet to be established. The purpose of this study was to elucidate the mechanisms regulating allergic inflammation based on circadian rhythms in order to alleviate clinical signs/symptoms of allergy constantly in line with the circadian rhythms of the body. By using a mouse model for human atopic dermatitis and dogs, time-of-day dependent variations of allergic inflammation were detected, and were shown to be controlled by glucocorticoid derived from the adrenal glands. These results suggested that administration of glucocorticoid drugs based on circadian rhythms might efficiently regulate allergic reactions.