Investigation on the preventive effect of the novel myokine Sparcon colon tumorigenesis

我们发现了一种新的肌肉分泌蛋白，分泌蛋白呈酸性且富含半胱氨酸（SPARC）。在这项研究中，我使用SPARC-null小鼠研究了新型肌因子SPARC对结肠肿瘤发生的预防作用。结果表明，定期低强度运动显著减少野生型小鼠结肠腺癌前体病变的形成，而运动没有抑制作用。此外，定期运动可增加野生型小鼠结肠细胞凋亡活性；然而，在久坐和运动的sparc缺失小鼠之间，这种活动并没有区别。这些结果表明，分泌蛋白SPARC可能通过增加caspase活性来抑制结肠肿瘤细胞的增殖。

We found a novel muscle-secreted protein, secreted protein acidic and rich in cysteine (SPARC). In this study, I have examined the preventive effect of the novel myokine SPARC on colon tumorigenesis using SPARC-null mouse. As a result, regular low-intensity exercise significantly reduced the formation of the precursor lesions of colon adenocarcinoma in wild-type mice, whereas exercise did not have an inhibitory effect. In addition, regular exercise increased apoptotic activity in the colon of wild-type mice; however, the activity did not differ between sedentary and exercised SPARC-null mice. These results suggest that the secreted-protein SPARC may suppress proliferation of colon tumor cells via increasing caspase activity.