Functional analysis of phosphoinositides in invasion and metastasis of breast cancer cells

侵袭伪足是由侵袭性癌细胞形成的膜突起，其介导细胞周围ECM的降解，并且在癌症转移期间与局部侵袭有关。在这项研究中，我们研究了磷脂酰肌醇代谢的作用，在invadopodium形成。我们发现PI3激酶p110α是人类癌症中经常突变的基因产物，参与乳腺癌细胞侵袭足的形成和侵袭。这一发现表明，通过p110α的信号通路是一个潜在的治疗癌症侵袭和转移的治疗靶点。

Invadopodia are membrane protrusions formed by invasive cancer cells that mediate degradation of pericellular ECM and have been implicated in local invasion during cancer metastasis. In this study, we investigated the role of phosphoinositide metabolism in invadopodium formation. We found that PI3 kinase p110α, a frequently mutated gene product in human cancers, is involved in invadopodium formation and invasion by breast cancer cells. This finding suggests that the signaling pathway via p110α is a potential therapeutic target for the treatment of cancer invasion and metastasis.