Identification and functional analysis of novel hypothalamic peptides
Identification and functional analysis of novel hypothalamic peptides
批准号:
20591100
负责人:
YAMAGUCHI Hideki
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We have identified two novel carboxy-terminally amidated peptides, Neuroendocrine regulatory peptide (NERP)-1 and NERP-2. Icv administration of NERP-2 increased food intake in rats. NERP-2 expression localized to the lateral hypothalamus, colocalizing with orexins that activate feeding behavior and arousal. Icv administration of NERP-2 also increased body temperature, oxygen consumption, and locomotor activity in rats. Bioactivities of NERP-2 were abrogated by blunting orexin signaling pathway. NERP-2 plays a role in the control of food intake and energy homeostasis via the orexin pathway.
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新規生理活性ペプチドNERPのヒト神経内分泌組織での局在
新型生物活性肽 NERP 在人类神经内分泌组织中的定位
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松尾崇, 山口秀樹, 影山晴秋, 佐々木一樹, 塩田清二, 南野直人, 中里雅光]
通讯作者:
中里雅光
Myasthenia gravis complicated with primary aldosteronism hypokalemic myopathy
重症肌无力并发原发性醛固酮增多症低钾性肌病
DOI:
--
发表时间:
2009
期刊:
Intern Med 48
影响因子:
--
作者:
[Yamashita S, Tsuchimochi W, Yonekawa T, Yamachi H, Kyoraku I, Shiomi K, Nakazato M]
通讯作者:
Nakazato M
新規視床下部ペプチドNERPによる水・電解質代謝調節
新型下丘脑肽 NERP 调节水和电解质代谢
DOI:
--
发表时间:
2008
期刊:
医学のあゆみ Vol 227
影响因子:
--
作者:
[山口秀樹, 中里雅光]
通讯作者:
中里雅光
Neuroendocrine regulatory peptides (NERPs) suppress presynaptic glutamatergic neurons and activate GABAergic interneurons to inhibit vasopressin secretion
神经内分泌调节肽 (NERP) 抑制突触前谷氨酸能神经元并激活 GABA 能中间神经元以抑制加压素分泌
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[岩崎泰正, 他。, 橋本貢士, 高野順子,高野幸路,山田正三,寺本明,高橋倫子,河西春郎,藤田敏郎, 山口秀樹]
通讯作者:
山口秀樹
DOI:
10.1016/j.regpep.2007.09.011
发表时间:
2008-01
期刊:
Regulatory Peptides
影响因子:
--
作者:
[H. Ueno;H. Yamaguchi;M. Mizuta;M. Nakazato]
通讯作者:
H. Ueno;H. Yamaguchi;M. Mizuta;M. Nakazato
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财政年份:2010
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批准号:20770108
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:YAMAGUCHI Hideki
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批准号:12470222
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2000
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负责人:YAMAGUCHI Hideki
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依托单位:
海外基金