Fabrication of epoxy-based molecular permeable membrane and analysis of membrane characteristics using coarse-grained molecular dynamics simulation

结合微流控系统的生物相容性渗透膜，允许具有一定分子量的生物分子扩散，在生物医学应用中是理想的。本研究采用粗粒度分子动力学模拟方法对环氧基化学放大光刻胶的分子渗透性进行了分子水平的研究。为了分析光刻胶中分子的力学性能和扩散系数，采用了具有扩展角度弯曲势的Kremer-Grest模型。仿真结果与实验结果具有相同的趋势，说明光刻胶膜可以通过改变光刻参数作为可控制渗透率的透膜。

Biocompatible permeable membranes integrated with a microfluidic system, which allow the diffusion of biological molecules with certain molecular weight, are desirable in biomedical applications. This study reports on a molecular level study of the molecules permeability of epoxy-based chemically-amplified photoresists by employing a coarse-grained molecular dynamics simulation. For analyzing mechanical property and diffusion coefficient of molecular in photoresists, Kremer-Grest model with an extended angle bending potential was employed. The simulation results show the same tendency with the experimental results, and which suggests photoresist membrane can be used as permeable membranes with controllable permeability by varying lithography parameters.