Dynamic Force Microscopy of small molecular assemblies.

操纵单个分子的可能性起初似乎是不真实的，事实上，5年前这是纯粹的科幻小说。 随着原子力显微镜（AFM）的普及，许多关于分子世界的观点正在发生变化。 现在讨论宏观效应，如粘附和润滑的光的测量与此仪器。 较新的工作包括观察单个蛋白质展开实验。 本申请中详细介绍的生物物理学导向项目将扩展AFM：进入自组装形成的多分子系统，如细胞膜;进入聚电解质表面相互作用;最后进入DNA测序。

The possibility of manipulating a single molecule seems at first unreal, indeed 5 years ago it was pure science fiction. Through the gaining popularity of the Atomic Force Microscope (AFM) many perspectives about the molecular world are changing. Macroscopic effects such as adhesion and lubrication are now discussed in light of measurements made with this instrument. Newer work includes the observation of single protein unfolding experiments. The biophysics oriented project detailed in this application will extend the AFM: into multi-molecular systems formed by self-assembly, such as cell membranes; into polyelectrolyte-surface interactions; and, finally into the sequencing of DNA.