The role of type I interferon for the lower respiratory infection induced by Haemophilus influenzae

本研究从组织侵袭能力，尤其是支气管上皮细胞侵袭能力方面探讨了流感嗜血杆菌引起慢性下呼吸道感染(CLRT)的机制。对21株流感嗜血杆菌临床分离株的组织侵袭能力进行了测定，各菌株之间的侵袭能力有显著差异。此外，与低侵袭性菌株相比，高侵袭性菌株感染的细胞株上清液中I型干扰素的产生明显增加。总的来说，I型干扰素具有抑制病毒感染的作用，但我们发现了I型干扰素促进流感嗜血杆菌诱导的LRT感染，这一发现将有助于阐明细菌cLRT的机制。

We examined the mechanism of chronic lower respiratory infection (cLRT) induced by Haemophilus influenzae with focusing the tissue-invasive ability especially bronchial epithelial cells. Twenty-one clinical isolates of H.influenzae were measured the ability of tissue-invasion and there were significant differences of the invasion ability between each strain. In addition, the production of type I IFN in the supernatant of the cell lines infected with high-invasive strains has increased significantly compared to the low-invasive strains.In general, type I IFN has the inhibitory effect against the viral infection, however we found new insight of type I IFN to accelerate the LRT infection induced with H.influenzae, and this finding will be contribute to elucidate the mechanism of bacterial cLRT.