Carcinogenesis of ovarian clear cell adenocarcinoma

卵巢透明细胞腺癌常与子宫内膜异位症相关，很少与腺纤维瘤相关。我们研究了腺纤维瘤相关CCA中编码ARID1A的BAF 250 a表达的缺失，并与乳腺癌相关CCA中的BAF 250 a表达进行比较。与子宫内膜异位症相比，腺纤维瘤单独CCA中BAF 250 a表达的缺失频率显著降低。

Ovarian clear cell adenocarcinoma (CCA) is frequently associated with endometriosis, and less often with adenofibroma. We investigated loss of BAF250a expression, which is encoded ARID1A, in adenofibroma-related CCA and compared with that in endometriosis-related CCA. Loss of BAF250a expression was significantly less frequent in adenofibroma alone CCA compared with endometriosis alone CCA.