Generation and transportation of biomolecules ions under super atmospheric pressure

质谱是生命科学发展中不可缺少的工具，要对样品进行质量分析，被分析物分子需要带电，而离子源是质谱中重要的关键部分。传统的方法是在高真空或常压下电离样品。在这项研究工作中，我们已经验证了可以通过增加离子源压力大于大气压力来提高电离性能。基于这一概念，我们开发了一系列新颖的电离源，不仅性能更好，而且还提供了传统方法无法实现的新应用。例如，我们能够以高灵敏度轻松处理分析水溶液，这对于蛋白质组学研究非常重要。这些研究成果不仅提高了质谱分析的性能，而且在薄膜沉积等其他领域提供了新的应用。

Mass spectrometry is an indispensable tool for life science development and to mass analyze the sample, analyte molecules need to be electrically charged and the ion source is an important key part in a mass spectrometer. Conventional methods ionize the sample either under a high vacuum, or under atmospheric pressure. During this research work, we had verified that it is possible to improve the performance of ionization by increasing the ion source pressure greater than the atmospheric pressure. Based on this concept, we have developed a series of novel ionization sources that not only perform better, but also offer novel applications that cannot be achieved by the conventional methods. For example, we are able to handle the analysis aqueous solution easily with high sensitivity, and this is important for proteomic study. These research outcomes not only improve the performance of mass spectrometry, but also offer new application in other area like thin film deposition.