Pharmaceutical development of functional food components based on pharmacokinetic properties

近年来，由于老年人在人口中所占比例的增加以及生活方式疾病患者的增多，预防医学和抗衰老医学受到了人们的广泛关注。本文对叶黄素这一功能性食品成分的吸收机理进行了详细的研究。Ezetimibe是一种NPC1L1 （Niemann-Pick C1-Like 1）抑制剂，可抑制cco -2细胞单层高达40%的叶黄素积累。我们的研究结果表明，叶黄素的吸收至少部分是由内流转运体NPC1L1介导的。然后制备了乳液，考察了提高吸收率的效果。我们的研究表明，胆汁和乳剂制剂对于辅酶Q10 （CoQ10）的吸收是必不可少的，辅酶Q10是一种亲脂性食品成分。像辅酶q10这样的高亲脂性化合物会扩散未搅拌的水层，并且通过含有高HLB（亲水亲脂平衡）值的表面活性剂的乳液很容易进入肠顶端膜。

Preventive medicine and anti-aging medicine have received much attention recently due to increases in the proportion of elderly people in the population and patients with lifestyle diseases. We investigated the absorption mechanism of lutein, a functional food component, in detail. Ezetimibe, an inhibitor of NPC1L1 (Niemann-Pick C1-Like 1), inhibited up to 40% of lutein accumulation by Caco-2 cell monolayers. Our results showed that lutein absorption is, at least in part, mediated by influx transporter NPC1L1. We then prepared some emulsions and investigated the effect the improvement the absorption. Our study suggests that Bile and emulsion formulation are essential for absorption of Coenzyme Q10 (CoQ10), a lipophilic food component. Highly lipophilic compounds like CoQ10 would diffuse the unstirred water layer and would easily access the intestinal apical membrane by an emulsion containing a surfactant with a high HLB (hydrophile lipophile balance)value.