Analysis of the effects of hypoxia inducible factor for tumor metastasis

缺氧诱导转录因子（Hypoxia inducible transcription factor，HIF）具有多种生理功能。在血管内皮细胞尾静脉注射转移模型中HIF功能分析的结果发现，移植到HIF-2alpah敲低的宿主小鼠中，转移灶减少。HIF-2 α基因敲除小鼠的内皮细胞中HIF-2 α的活性较低。此外，HIF-3 α抑制肺血管内皮细胞的缺氧反应是通过抑制VE-cadherin的表达来调控的。我们发现当HIF-2 α降低到阈值以下时，HIF-1apha代偿性激活的现象。

Hypoxia inducible transcription factor (HIF) has various physiological functions. The results of the HIF functional analysis in vascular endothelial cells with tail vein injection metastasis model, we found that metastasis foci was reduced when transplanted into HIF-2alpah knockdown host mice. HIF-2alpa knockdown mice have low activities in HIF-2alpha in endothelial cells. Furthemore, HIF-3alpha acting on inhibitory to the hypoxic response is controlling to the inhibitory VE-cadherin expression in pulmonary vascular endothelial cells. We found the phenomenon that HIF-1apha is activated in compensatory when HIF-2alpha was reduced to a certain level below threshold.