マヌカハニー摂取による大腸がん予防機構の解明に向けたニュートリオミクス研究

在这一年中，我们在去年制作的动物模型中使用不同的食品（麦卢卡蜂蜜，米糠和大豆）进行了筛选实验。不幸的是，麦卢卡蜂蜜和大豆补充剂并没有改善结肠炎。因此，我们旨在阐明米糠（RB）饮食干预对2.0%葡聚糖硫酸钠(DSS)-包括结肠炎C57BL/6L小鼠模型的分子机制。br喂养小鼠的体重减轻、疾病活动指数、结肠长度和结肠组织病理学均有改善。随着时间的推移，微生物组和代谢组的结果表明，与rb相关的肠道环境改变可以通过建立肠道稳态来预防结肠炎。我们的方法是开发RB新治疗应用的重要工具。

In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.