INFORMATION PROCESSING IN CEREBELLAR FLOCCULUS FUNCTIONAL ZONE

我们研究了警觉猫在视动反应(OKR)过程中，小脑小脑小叶中区浦肯野细胞的单峰频率(SS)与眼动的相关性。用决定系数&GT很好地重建了给定时间延迟(平均为11INS)时的时间历程；通过眼球加速度(平均系数，0.076次/S/度)、速度(5.19次/S/度/S)、位置(-2.89次/S/度)和偏差(平均35.8次/S)的线性加权叠加，估计了各成分对回归的贡献大小，发现有三种细胞类型：速度-位置-加速度(n=19)，速度、位置和加速度分量的贡献显著(P&lt；0.05)；速度-位置型(VP)型(n=9)，速度和位置分量显著，速度-加速度(VA)型(n=2)，速度和加速度分量显著。使用5°/S刺激速度的一组系数，成功地重建了较高刺激速度(10、20和40°/S)下的SS率，表明该模型具有通用性。在OKR期间，在SS-FIRING中编码的眼睛位置信息是相对的，但不是绝对的，因为无论初始眼睛位置如何，位置移位的大小都有助于激发速率的变化。结果表明：1)在短时水平OKR过程中，CAT中间区的瞬时SS发射频率分别编码了控制粘滞力和惯性力的速度和加速度信息；2)SS发射过程中所编码的位置信息不足以控制OKR过程中的弹性力。

We investigated correlation between the eye movement and temporal simple-spike (SS) frequency of the Purkinje cell in the cerebellar flocculus middle-zone during optokinetic response (OKR) in alert cats. Time course of the temporal SS-rate at a given time delay (mean, 11 ins) was well reconstructed with coefficient of determination > 0.7 by a linear weighted superposition of the eye acceleration (mean coefficient, 0.076 spikes/s per deg/s2), velocity (5.19 spikes/s per deg/s), position (-2.89 spikes/s per deg), and bias (mean, 35.8 spikes/s), Magnitude of the contribution of each component to the regression was estimated, and three cell types were found : Velocity-Position-Acceleration (VPA) type (n=19), contribution of velocity, position, and acceleration components is significant (P < 0.05) ; Velocity-Position (VP) type (n=9), velocity and position components are significant ; Velocity-Acceleration (VA) type (n=2), velocity and acceleration components are significant. Using a single set of the coefficients for 5 deg/s stimulus velocity, the SS rate during higher (10, 20, and 40 deg/s) stimulus velocities were successfully reconstructed, suggesting generality of the model. The eye-position information encoded in SS-firing during OKR is relative but not absolute in the sense that the magnitude of the position shift contributes to the firing-rate change regardless of the initial eye-position. It is concluded that 1) the temporal SS-firing frequency in the cat middle-zone encodes the velocity and acceleration information for controlling the viscosity- and inertia-forces, respectively, during short-duration horizontal OKR and 2) the position information encoded in the SS-firing is not sufficient for controlling the elastic force during] OKR.