Molecular control of cell migration during Xenopus gastrulation by different Wnt signaling pathways

脊椎动物胚胎背侧中胚层的会聚伸展(CE)运动对脊椎动物胚胎背侧体轴的形成有重要贡献。在我们以前的研究中，我们已经确定Protocadherin XPAPC是一个关键分子，它受Wnt-5A/Ror2信号级联反应的调控，并与Wnt/PCP途径相互作用，协调非洲爪哇CE的运动。我们未来的研究将集中在(1)新的Wnt-5A/Ror2信号通路的进一步表征，包括鉴定额外的效应蛋白，(2)两个非典型Wnt信号通路的功能和分子相互连接，以及(3)它们的进化保守性。后者是通过整合到研究单位而产生的一个新方面。通过物种间功能研究，Wnt-5a/Ror2和Wnt/PCP通路在水产再生和小鼠心肌重塑过程中的生理作用的保守性将得到解决。

Convergent extension (CE) movements of the dorsal mesoderm make a major contribution to shaping the dorsal body axis of vertebrate embryos. In our previous research we have identified the protocadherin XPAPC as a key molecule that is regulated by the Wnt-5A/Ror2 signaling cascade and interacts with the Wnt/PCP pathway to coordinate CE movements in Xenopus laevis. Our future research will focus on (1) further characterization of the novel Wnt-5A/Ror2 pathway, including identification of additional effector proteins, (2) the functional and molecular interconnection of both non-canonical Wnt-signaling pathways and (3) on their evolutionary conservation. The latter is a novel aspect that arises by the integration into the research unit. By interspecies functional studies the conservation of the physiological role of Wnt-5a/Ror2 and Wnt/PCP pathways will be addressed in processes of Hydra regeneration and mouse myocardial remodeling.