Comparative Study of Salt Sensitivity and Heredity in Nepal

我们发现，在一个尼泊尔山区（Kotyang）村庄的居民中，高血压患者很少，尽管他们的盐摄入量与包括日本在内的许多西方国家的公民一样高。为了评估参与这种现象的遗传因素，我们研究了他们是否有一个特殊的基因型分布的血管紧张素转换酶（ACE）基因L/D多态性，这是最近报道的参与盐敏感性。在尼泊尔Kotyang村对138名受试者（年龄范围为20至84岁）进行了评价。该人群中只有9名受试者（6.5%）是高血压患者（140/90 mmHg及以上），同时每天摄入11- 12 g盐，这也证实了先前的结果。ACE基因I/D多态性的基因型和等位基因分布与日本人和中国人相似，日本人和中国人的高血压患病率是尼泊尔人的5 ~ 10倍，而与高加索人的差异有统计学意义。本研究报告，第一次，ACE基因I/D多态性的基因型分布在尼泊尔的主题。ACE基因多态性可能与该群体的耐盐性无关。

We found that there were very few hypertensive subjects in the inhabitants of one Nepalese hill (Kotyang) village, even though their salt consumption was as high as the citizens in many westernized countries including Japan. To evaluate the genetic factors involved in this phenomenon, we studied whether or not they had a special genotype distribution of angiotensin converting enzyme (ACE) gene L/D polymorphism, which was recently reported to be involved salt sensitivity. One hundred and thirty-eight subjects (aged in range 20 to 84 years) were evaluated at Kotyang village in Nepal. Only 9 subjects (6.5%) in this population were hypertensives (140/90 mmHg and over) while consuming 11-12g per day of salt, which also confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-to ten-times -more hypertensives while consuming almost as much salt as Nepalese, but signiticantly different from those in Caucasians. The present study reports, for the first time, the genotype distribution of ACE gene I/D polymorphism in Nepalese subjects. Furthermore, the results suggest ACE gene polymorphism may not be involved in the 'salt-resistance' in this population.