Molecular System Designing for Capillary Electrophoresis

The aim of this research project is The exploitation of a 'chemical system' approach to novel CEseparation modes for metal complexes via a better underlying of the underlying solution chemistrythe CE separation.(1) Ionic mobilities are controlled by ion-ion interactions in electrophoreticbuffer solutions；polymer electrolyte such as poly(diallyldimethyl ammonium chloride) was found to bevery effective for the fine separation of anionic metal chelates of polyaminocarboxylates， EDTA，quin 2,Polyaminocarboxylate ligands possessing phenolate moieties were sought；the CE selectivity of HBED towards trivalent metal ion was demonstrated and a dibromo derivative，D22 D2HBED was prepared and the reaction with Fe(III) ion was examined.(3) the uniqueselectivity of phenylenediamine-N，N，N‘，N’-tetraacetate towards Ca(II) ion was found.(4) A novelclass of metal-ligating functions， thiacalix[4]arenes are exploited for the metal CE分析；The selective oxidation方法for The sulfur atoms which is linking four phenol moieties werefirst reported. This doubtless expands the metal selectivity control of the thiacalix[4]arenes viaproduction of the sulfone and sulfoxide derivatives。

The aim of this research project is the exploitation of a 'chemical system' approach to novel CE separation modes for metal complexes via a better understanding of the underlying solution chemistry of the CE separation.(1) Ionic mobilities are controlled by ion-ion interactions in electrophoretic buffer solutions ; an addition of polymer electrolyte such as poly(diallyldimethyl ammonium chloride) was found to be very effective for the fine separation of anionic metal chelates of polyaminocarboxylates, EDTA, Quin 2, and HBED complexes.(2) Polyaminocarboxylate ligands possessing phenolate moieties were sought ; the CE selectivity of HBED towards trivalent metal ion was demonstrated and a dibromo derivative, BrィイD22ィエD2HBED was prepared and the reaction with Fe(III) ion was examined.(3) The unique selectivity of phenylenediamine-N,N,N',N'-tetraacetate towards Ca(II) ion was found.(4) A novel class of metal-ligating functions, thiacalix[4]arenes are exploited for the metal CE analysis ; The selective oxidation methods for the sulfur atoms which is linking four phenol moieties were first reported. This doubtless expands the metal selectivity control of the thiacalix[4]arenes via the production of the sulfone and sulfoxide derivatives.